Point-of-care CD4 Cell Counting for Monitoring HIV/AIDS Patients in Resource-confined Regions

##plugins.themes.bootstrap3.article.main##

##plugins.themes.bootstrap3.article.sidebar##

PDF
Published Jul 14, 2017
DOI https://doi.org/10.36001/phmap.2017.v1i1.2064
Jung Kyung Kim
School of Mechanical Engineering, Kookmin University, Seoul 02707, Republic of Korea
Myoung-Ock Cho
School of Mechanical Engineering, Kookmin University, Seoul 02707, Republic of Korea
Subin Kim
Department of Mechanical Engineering, Graduate School, Kookmin University, Seoul 02707, Republic of Korea
Mohiuddin Khan Shourav
Department of Mechanical Engineering, Graduate School, Kookmin University, Seoul 02707, Republic of Korea

Abstract

We developed a prototype of optical imaging-based pointof-care (POC) devices that can detect CD4+ T-lymphocytes in human blood for HIV/AIDS monitoring. The proposed portable cell-counting system, Helios CD4, can acquire sample images and analyze particles or cells automatically, by using a simple imaging module and a sample cartridge with a three-dimensional (3D) helical mini-channel. This device has advantages over the existing devices because of its small size and simple scanning mechanism. A performance evaluation was conducted by comparing the cell count obtained using Helios with that obtained using PIMA, one of the most widely used POC CD4+ cell counter.

Abstract 39 | PDF Downloads 65

##plugins.themes.bootstrap3.article.details##

Keywords

PHM

References
Burger, W. & Burge, M. J. (2016) Digital image processing: an algorithmic introduction using Java, Springer
Cho, M.-O., Yoon, S., Han, H. & Kim, J. K. (2011) Automated counting of airborne asbestos fibers by a high-throughput microscopy (HTM) method, Sensors, vol. 11. pp. 7231-7242.
Kirby, D., Glynn, M., Kijanka, G. & Ducree, J. (2015) Rapid and cost-efficient enumeration of rare cancer cells from whole blood by low-loss centrifugomagnetophoretic purification under stopped-flow conditions. Cytometry Part A, vol. 87A, pp. 74-80.
Larson, B., Schnippel, K., Ndibongo, B., Long, L., Fox, M. P. & Rosen, S. (2012) How to estimate the cost of point-of-care CD4 testing in program settings: an example using the Alere PimaTM Analyzer in South Africa. PLOS One, vol. 7, pp. 1-8.
Issue
Vol. 1 No. 1 (2017): Proceedings of the Asia Pacific Conference of the PHM Society 2017
Section
Special Session Papers